B-Direct with Coenzyme B Vitamins

Vitamins are organic compounds needed in small amounts in the diet that are critical to life.  They help regulate body processes such as assisting in the release of energy, DNA synthesis, maintaining cellular growth and proliferation, facilitating the production of neurotransmitters, and many, many more. They are categorized as either fat soluble or water soluble.  Vitamins A, D, E, and K are those that are fat soluble.  The water soluble vitamins are those in the B complex (thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, and biotin) plus vitamin C.

Vitamins often exist as provitamins, their inactive forms, and must be converted into their active forms before they can perform metabolic tasks in the body’s cells.   Vitamins are activated in the body by phosphorylation (adding a phosphate [-PO4] group) or methylation (adding a methyl [-CH3] group).  For example, vitamin B12 is absorbed from food as cobalamin in a complex with intrinsic factor, a binding protein that allows for B12 absorption.  Once absorbed, the body releases intrinsic factor and adds a methyl group to convert B12 to its active form: methylcobalamin.  In its active state, methylcobalamin aids in single carbon, folate, and homocysteine metabolism, as well as in DNA and red blood cell synthesis.  Methylcobalamin is also critical in the normal growth of nerve cells.

Some examples of vitamins and their coenzyme forms:


Coenzyme form

  Vitamin B1 (Thiamin)

Thiamin cocarboxylase

  Vitamin B2 (Riboflavin)

Riboflavin 5’ phosphate


Nicotinamide adenine dinucleotide (NADH) or Nicotinamide adenine dinucleotide phosphate (NADPH)

  Vitamin B6

Pyridoxine 5’ phosphate



  Vitamin B12


While most individuals can readily convert provitamins into their active state, some cannot.  Those individuals can be nutritionally deficient or have a genetic variation that does not allow for the conversion to the active coenzymes.   By supplementing with the already active, coenzyme forms of various vitamins, they can be immediately utilized by the body.

Reasons for B vitamin deficiencies include:

·       weight loss diets/fasts

·       high daily intakes of sugar, refined and processed foods

·       high daily intakes of caffeine, saccharine and alcohol.

·       stress

·      medications, especially antibiotics, diuretics, chemotherapy, the birth control pill, hormone replacement therapy


Coenzyme B vitamins are beneficial for:

·       improving energy levelst

·       supporting brain/cognitive health and moodt

·       supporting cellular healtht

·       supporting cardiovascular healtht

·       improving healthy hair, skin and nailst

·       elevating moodt

·       generating energy and endurancet

·       supporting immune functiont

·       and many more!


Bluebonnet offers an entire family of Coenzyme B vitamins providing a full spectrum of pure, high potency, water-soluble B vitamins, which play important roles in cellular metabolism, in complete coenzyme forms for enhanced bioavailability from vegetarian sources that are also kosher-certified, gluten-free truly vegan coenzyme B formulas inside and out.

·       CellularActive® Coenzyme B-Complex Vegetable Capsules

·       CellularActive® P-5-P 50 mg Vegetable Capsules

·       Liquid CellularActive® Methylcobalamin Vitamin B12 1000 mcg

·       Liquid CellularActive® Methylcobalamin Vitamin B12 5000 mcg

·       EarthSweet® Chewables CellularActive® Methylcobalamin 1000 mcg Tablets

·       EarthSweet® Chewables CellularActive® Methylcobalamin 5000 mcg Tablets

·       EarthSweet® Chewables CellularActive® Methylfolate 400 mcg Tablets

·       EarthSweet® Chewables CellularActive® Methylfolate 800 mcg Tablets

·      EarthSweet® Chewables CellularActive® Methylfolate 1000 mcg Tablets



Mahan LK, Escott-Stump S. Krause’s Food, Nutrition, & Diet Therapy, 11th ed.  2000. Vitamins. 


Miller AL.  The methylation, neurotransmitter, and antioxidant connections between folate and depression. 2008.  Altern Med Rev. 13(3):216-26.


Neiva, R.F., Al-Shammari, K., Nociti, F.H., et al.  2005.  Effects of Vitamin-B Complex Supplementation of Periodontal Wound Healing.  J Periodontol.  76(7):1084-1091.


Smith, A.D., Smith, S.M., Jager, C.A., et al.  2010.  Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial.  PLos One.  5(9): e12244.  doi: 10.1371/journal.pone.0012244.


Ubbink, J.B., Vermaak, W.J.H., van der Merwe, A., et al.  1993.  Vitamin B-12, vitamin B-6, and folate


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