Methylcobalamin: The CellularActive® Vitamin B12

Summer is over and the kids are back in school.  You undoubtedly have a mile long to-do list and there just aren’t enough hours in the day to get it all done.  We get it – you’re stressed and you’re tired.  One of best methods for combatting exhaustion is to maintain a healthy lifestyle.  By taking care of yourself, you are providing the body with the essentials it needs to cope with stress.  For example, key nutrients can help to elevate your mood and generate energy to allow you to make it through the day, and you may just be able to cross off a couple more items on that list.  One such nutrient is methylcobalamin.

Methylcobalamin is the metabolically active coenzyme form of vitamin B12 that is available for immediate use by the body1.  Its inactive precursor, cyanocobalamin, is the principal form of the vitamin used in the fortification of foods and in nutritional supplements2.  Once ingested and absorbed, cyanocobalamin is then converted into methylcobalamin in the liver by adding a methyl group and the result is a more bioavailable and better utilized form of B122.   Vitamin B12 is needed for the maintenance of the nervous system, the production of energy, the synthesis of molecules such as RNA and DNA, and the production of red blood cells2.

Specifically, vitamin B12, as methylcobalamin, is the perfect adjunct for:

Elevating Mood ♦ 

· Vitamin B12 deficiency depletes the levels of S-adenosylmethionine (SAMe) – a nutrient that has powerful mood-elevating properties – in the body3. SAMe is involved in the production and break down of brain chemicals, such as serotonin, melatonin, and dopamine.  These chemicals are known as catecholamines and are identified as important neurotransmitters in maintaining the affective (emotional) state4.

Generating Energy & Endurance ♦ 

· Vitamin B12 reduces the symptoms of fatigue by providing oxygenated red blood cells throughout the body5.  Additionally, B12 is involved in the conversion of carbohydrates, proteins and fats into energy that is used to perform bodily functions as well as support growth and development2.

By supplementing with the active coenzyme form of B12, methylcobalamin, you are better equipped for supporting your mood and increasing energy and endurance.  While, the current recommended daily value for vitamin B12 is 2.4 mcg2, the consensus among scientists today, based on recent evidence, suggests that vitamin B12 intakes well above current recommendations may be associated with better health outcomes in individuals with a deficiency2.


Bluebonnet now provides EarthSweet® Chewables CellularActive® Methylcobalamin 1000 & 5000 mcg Tablets plus, our award-winning Liquid CellularActive® Methylcobalamin 1000 & 5000 mcg potencies which may be better utilized and retained in the body. 


1. Hemendinger RA, Armstrong EJ, Brooks BR.  Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death.  Toxicology and Applied Pharmacology. 2011; 251: 217-225.

2. National Institutes of Health – Office of Dietary Supplements.  Dietary Supplement Fact Sheet: Vitamin B12.  Accessed from on 9/17/14.

3. Scott JM, Molloy AM, Kennedy DG, et al.  Effects of the disruption of transmethylation in the central nervous system: an animal model. Acta Neurol Scand Suppl. 1994; 154: 27-311.

4. Bottiglieri T.  S-Adenosyl-L-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule.  Am J Clin Nutr. 2002;76(suppl):1151S–7S.

5. Huijts M, Duits A, Staals J, et al.  Association of Vitamin B12 Deficiency with Fatigue and Depression after Lacunar Stroke.  PLoS ONE.  2012; 7(1).


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